an efficient synthesis of 3,4-dihydropyrimidin-2-(1h)-one derivatives promoted by antimony trichloride under thermal and solvent-free conditions

an efficient and simple one-pot approach for the synthesis of 3,4-dihydropyrimidin-2-(1h)-one derivatives using antimony trichloride (sbcl3) as a mild catalyst by means of three-component biginelli reaction between β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with excellent yields and short reaction times is reported. this methodology offers several merits such as excellent yields, short reaction times, efficient, eco-friendly, solvent-free conditions, materials available, and simple operational procedure with no column chromatographic separation. the products are characterized by melting points and 1h nmr spectroscopy.